Two Rochester brothers are accused of trafficking large amounts of cocaine and fentanyl.
41-year-old Andy Rucci and 38-year-old Joel Rucci are charged with conspiracy.
Federal prosecutors say they found about 6 kilos of cocaine in Joel's car during a traffic stop last month.
And a raid on a Mathews Street home netted other drugs and $25,000 in cash.
Both brothers have previous drug convictions.