Receiver Gabe Davis had two long touchdown catches as the Bills crushed the Steelers 38-3 at home.
The first was a 98-yard bomb, and the second was a 62-yarder in which Davis wrestled for the ball with Steelers safety Minkah Fitzpatrick.
Josh Allen threw for a career high 424 yards and four touchdowns.
Rookies Khalil Shakir caught his first touchdown pass
The Bills improved to 4 and 1 and will travel to Kansas City on Sunday.